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KMID : 0613820120220030318
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Journal of Life Science
2012 Volume.22 No. 3 p.318 ~ p.323
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Effects of Doinsenggitang on Melanin Synthesis and Gene Expression Inhibition in B16F10 Melanoma Cells
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Hwang Ju-Young
Kim Dong-Hee
Kim Hui-Jung
Hwang Eun-Young
Park Tae-Soon
Lee Jin-Young
Son Jun-Ho
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Abstract
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This study involved observation of the inhibitory effect of 70% EtOH and water extracts from Doinseunggitang on melanin synthesis, tyrosinase activity, and western blotting using B16F10 melanoma cells. Doinseunggitang extracts inhibited melanin synthesis and tyrosinase activity in a dependent manner. As a result, it was found that Doinseunggitang 70% EtOH extracts inhibit melanin synthesis and tyrosinase activity, respectively, by 40% and 51%. In addition, western blotting analysis showed that 70% EtOH extracts inhibited tyrosinase, MITF, TRP-1, and TRP-2 expression. These results show that 70% ethanol extracts of Doinseunggitang could be developed as a skin whitening material in cosmetics.
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KEYWORD
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Doinseunggitang, tyrosinase, microphthalmia transcription factor, tyrosinase related protein
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